Closing in on sub-segmentation in type 2 diabetes in the Danish nationwide DD2 cohort - circulating biomarkers

Abstract

The multiplex technology allows multiple measurements of circulating biomarkers with high throughput, precision and accuracy. Using custom-made multiplex MSD panels, we will measure a range of biomarkers involved in metabolism, oxidation, inflammation, cardiac load, fibrosis, coagulation, calcium metabolism or kidney function as shown. The biomarkers are selected based on an a priori hypothesis of each having high subsegments category defining and/or prognosis predicting
potential.

Formål

1. To validate, refine and/or redefine the proposed novel T2D subsegments (SS)
2. To characterize in-depth the etiologies and disease mechanisms of distinct T2D SS
3. To examine treatment responses, disease trajectories and outcomes over time in different T2D SSs

Studiepopulation

Our main cohort will consist of the current 9,184 (as of September 2020) DD2 patients with a new T2D diagnosis at enrolment (median age 61 years, 58% male). The median follow-up will be 6.5 years end 2020.

Artikler

• Kristensen and Domazet (2024). Elevated risk of infection in individuals with hyperinsulinaemic type 2 diabetes: a Danish 12 year cohort study. Diabetologia
• Domazet (2024). Low-grade inflammation in persons with recently diagnosed type 2 diabetes: The role of abdominal adiposity and putative mediators. Diabetes Obes Metab.
• Abstract - Bennetsen (2024). Circulation levels of interleukin-6 predict risk of obesity-related cancers in patients with recently diagnosed type 2 diabetes
• Abstract - Thomsen (2024). Association of educational level with clinical presentation and pharmacological treatment in 10.020 individuals with recently diagnosed type 2 diabetetes
• Abstract - Domazet (2024). Prospective associations between markers of low-grade inflammation and major cardiovascular events and mortality in recently diagnosed type 2 diabetes
• Abstract - Nielsen (2024). Infection risk is substantially increased in a hyperinsulinaemic type 2 diabetes subgroup: a Danish cohort study
• Abstract - Domazet (2023). Mediation of the association between abdominal adiposity and subclinical inflammation in type 2
  diabetes
• Abstract - Olesen (2023). Age-dependent association of NT-proBNP with obesity, insulin resistance and inflammation in type 2 diabetes 
• Abstract - Christensen (2022). EASD2022
• Abstract - Kjærgaard (2022). EASD2022

Finansiering

Novo Nordisk Fonden