Coronary plaque morphology and plaque progression in patients with newly diagnosed type-2 diabetes mellitus

Abstract

The increasing prevalence of diabetes mellitus worldwide has led to a situation where approximately 360 million people had diabetes mellitus in 2011, of whom more than 95 % had type II diabetes mellitus (T2DM).

T2DM and pre-diabetic changes in glucose metabolism are risk factors for cardiovascular disease which account for 50-75 % of deaths in T2DM. There is only sparse information regarding the atherosclerotic burden and cardiovascular biomarkers in the early stages of T2DM. It is important to recognize cardiovascular risk factors and modify them if possible by primary and secondary intervention.

This Ph.D. study aims at evaluating the occurrence of early-stage subclinical atherosclerosis in newly diagnosed T2DM with special emphasis on coronary plaque characteristics by modern imaging techniques. These findings will be compared to the morphological and functional status of various peripheral arterial segments and biomarkers. The progression of these changes will be studied in 5 years follow up.

Formål

1. Compare the prevalence and complexity of coronary plaques in patients with newly discovered T2DM with a healthy control group matched for age and gender, as evaluated by CCTA.  

2. Describe the relationship between morphological, functional and biochemical estimates of arteriosclerosis in newly diagnosed T2DM.

3. Characterize the progression of coronary plaques in patients with newly discovered T2DM in a 5-year follow-up study.

Studiepopulation

Inclusion criteria

• Newly diagnosed (< 1 year) diabetes patients clinically classified as T2DM patients of both sex.
• Age 18 +

Artikler

• Mrgan (2020). Coronary flow impairment in asymptomatic patients with early stage type-2 diabetes: Detection by FFR CT. Diab Vasc Dis Res.
• Mrgan (2018). Sex differences in coronary plaque composition evaluated by coronary computed tomography angiography in newly diagnosed Type 2 diabetes: association with low-grade inflammation. Diabet Med.
• Mrgan (2017). High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes. Diab Vasc Dis Res.