DD2 cohort profile

Abstract

The DD2 cohort continuously enrols newly diagnosed patients with type 2 diabetes (T2D) throughout Denmark. The overall goal of the DD2 project is to establish a large and data-rich T2D cohort that can serve as a platform for exhaustive T2D research including (1) improved genotypic and phenotypic characterisation of T2D, (2) intervention studies of more individualised T2D treatment, (3) pharmacoepidemiological studies and (4) long-term follow-up studies on predictors of T2D complications and prognosis

Studiepopulation

Patients with diagnosed type 2 diabetes within the last 24 month. 

Artikler

• Sørensen (2024) - Rare MTNR1B variants causing diminished MT2 signalling associate with elevated HbA1c levels but not with type 2 diabetes. Diabetologia.
• Kristensen (2024) - The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project Cohort and Biobank from 2010 Through 2023 - A Cohort Profile Update. Clinical Epidemiology.
• Kizilkaya (2024) - Characterization of genertic variants of GIPR reveals a contribution of beta-arrestinto metabolic phenotypes. Nature Metabolism.
• Melchiorsen (2023). Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes. The Journal of Clinical Endocrinology & Metabolism.
• Christensen (2022). Type 2 diabetes classification - a data-driven cluster study of the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. BMJ Open Diabetes Research and Care.
• Christensen (2018). Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project cohort of newly diagnosed patients with type 2 diabetes: a cohort profile. BMJ open.
• Gedebjerg (2018). Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: a cross-sectional baseline study of 6958 patients ind the Danish DD2 cohort. Journal of Diabetes and its Complications.
• Ugeskrift for læger (2014). DD2 - nye veje i behandlingen af type 2 diabetes. 
• Christensen (2012). New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2). Clinical epidemiology.
• Steffensen (2012). The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project: rationale and planned nationwide studies of genetic predictors, physical exercise, and individualized pharmacological treatment. Clinical epidmiology. 
• Sørensen (2012). The Danish national type 2 diabetes cohort – the DD2 study. Clinical epidemiology.
• Thomsen (2012). The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) study: Collection of baseline data from the first 580 patients. Clinical epidemiology.
• Beck-Nielsen (2012). The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) study: expected outcome from the DD2 project and two intervention studies. Clinical epidemiology.
• Nielsen (2012). The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) study: implementation of a nationwide patient enrollment system. Clinical epidemiology.
• Thomsen (2012). The Danish Centre for Strategic Research in Type 2 Diabetes (DD2): organization of diabetes care in Denmark and supplementary data sources for data collection among DD2 study participants. Clinical epidemiology.