Abstract
Around 3-10% of patients clinically diagnosed with type 2 diabetes (T2D) have circulating autoantibodies as seen in type 1 diabetes (T1D). This diabetic subtype is termed latent autoimmune diabetes in adults (LADA), and is the second most common type of diabetes only exceeded in numbers by T2D. Initially LADA is controlled with diet and oral antihyperglycemic drugs, but these patients usually end up requiring insulin. The diagnostic criteria for LADA are debated, and the etiology is largely unknown even though mechanisms underlying both T1D and T2D seem to be involved. An obvious way to improve the classification of LADA, is to determine to what degree LADA shares genetic predisposition with T1D and T2D, and whether LADA has its own set of susceptibility gene variants. Therefore, we wish to identify a sufficiently large cohort of patients with LADA (at least 1000 patients) through national cooperation, to carry out well powered candidate gene studies of known T1D and T2D gene variants in these patients, and further through international cooperation to carry out a genome-wide association of LADA. We expect that the results will improve the diagnostic characterization of LADA, improve it’s the separation from T1D and T2D, and lead to development of better and possibly individualized treatment of patients with LADA.
Formål
1. Identify Danish LADA patients by analyzing GADA in >10,000 type 2 diabetes patients, including all available DD2 patients (n=5700)
2. Perform a candidate-gene study in the identified LADA patients (including those from DD2) assessing all known T1D and T2D associated variants, in order to characterize the genetic overlap between the diabetic subtypes
3. Perform a genome-wide association study including the identified Danish LADA patients (Including those from DD2) as well as LADA patients collected by international collaborators in order to identify novel LADA associated variants
Finansiering
Det Frie Forskningsråd
DD2 er ledet af Steno Diabetes Centrene
