Insulin and bone turnover in type 2 diabetes

Abstract

Bone turnover is decreased in type 2 diabetes. Lack of insulin may impair bone formation, and insulin resistance in bone cells may reduce the bone anabolic effects of insulin. The importance of presence of high or low levels of insulin on bone turnover in T2D has not been investigated. The primary aim of this study is to compare levels of markers of bone formation in treatment-naïve individuals with T2D. Difference in bone resorption is considered a secondary outcome.

Formål

1. Are bone formation (Primary outcome) and resorption (secondary outcome) higher in antidiabetic treatment-naive patients with T2D with high insulin concentrations than in antidiabetic treatment-naive T2D patients with low insulin levels?

2. Is increased glucose level associated with low bone turnover in treatment-naive patients with T2D (exploratory outcome)?

Studiepopulation

Type 2 diabetes (normal no GAD-Abs)

Artikler

• Nasser (2023). Low Bone Turnover Associates With Lower Insulin Sensitivity in Newly Diagnosed Drug-Naïve Persons With Type 2 Diabetes.The Journal of Clinical Endocrinology & Metabolism. 

Finansiering

MFN (Research grant from Independent Research Council)