Abstract
Diabetic polyneuropathy (DN) affects 30-50% of diabetes patients and is, besides sensory discomfort and pain, associated with substantial other morbidity including diabetic foot ulcers and diabetic lower extremity amputations leading to substantial health care costs, and high mortality. Understanding of risk factors and exact mechanisms behind DN is patients with type 2 diabetes (T2D) is lacking, hampering the development of disease-modifying treatment as well as protection against development of DN. As opposed to type 1 diabetes (T1D), clinical trials show only modest (if any) reduction in DN risk associated with strict glycemic control in T2D. Elements of the metabolic syndrome may play a central role in development of DN in T2D. Pain is a major problem in DN, however only for a proportion of DN-patients, and predictors of pain development is fairly unknown. A questionnaire-survey of self-reported DN, painful symptoms and psychosocial comorbidity in the DD2 cohort with additional data from high-quality nationwide health registries has been planned as a collaboration between the International Diabetic Neuropathy Consortium (IDNC) and the DD2. The overall aim is to evaluate prevalence of and predictors for painful and non-painful DN as well as the association of DN with mood, anxiety, sleep quality and quality of life. A subcohort of the DD2 patients who have self-reported DN will later be invited for a detailed clinical examination in the IDNC.
Formål
- To evaluate the prevalence of self-reported painful and non-painful DN in a well-characterized cohort of newly diagnosed T2D patients.
- To determine predictors of DN including potentially modifiable metabolic, clinical and lifestyle factors.
- To examine the association of painful and non-painful DN with factors like mood, anxiety, sleep quality and quality of life
Studiepopulation
The study will rely on the population of incident type 2 diabetes patients enrolled in the DD2 with additional data from the Danish Diabetes Database for Adults (DDDA).
Artikler
- Peters (2023). Cardiovascular autonomic neuropathy in patients with type 2 diabetes with and without sensorimotor polyneuropathy. J peripher Nerv Syst.
- Kristensen (2023). The Prevalence of Polyneuropathy in Type 2 Diabetes Subgroups Based on HOMA2 Indices of b-Cell Function and Insulin Sensitivity. Diabetes Care.
- Abstract - Kristensen (2022). EASD2022
- Itani 2022 - Comparison of diabetic and idiopathic sensory polyneuropathies with respect to nerve fibre affection and risk factors. BMJ Neurol Open
- Bjerg (2021). Diabetic Polyneuropathy Early in Type 2 Diabetes Is Associated With Higher Incidence Rate of Cardiovascular Disease: Results From Two Danish Cohort Studies. Diabetes Care.
- Itani (2021). Small and large fiber sensory polyneuropathy in type 2 diabetes: Influence of diagnostic criteria on neuropathy subtypes. Journal of the peripheral nervous system.
- Gylfadottir (2020). Diagnosis and prevalence of diabetic polyneuropathy: a cross‐sectional study of Danish patients with type 2 diabetes. European journal of neurology.
- Christensen (2020). Metabolic factors, lifestyle habits and possible polyneuropathy in early type 2 diabetes: A nationwide study of 5,249 patients in the Danish Centre for Strategic Research in Type 2 diabetes (DD2) cohort. Diabetes Care.
- Gylfadottir (2020). Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes. Pain.
- Abstract - Bjerg (2019). Early indication of diabetic neuropathy is associated with higher risk of subsequent cardiovascular disease in screen-detected type 2 diabetes. Diabetologia.
- Abstract - Gylfadottir (2017). Painful diabetic polyneuropathy and quality of life in Danish type 2 diabetic patients. Scandinavian Journal of Pain.
Finansiering
The International Diabetic Neuropathy Consortium
DD2 er ledet af Steno Diabetes Centrene
